Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone
نویسندگان
چکیده
Purpose To assess whether CT-based radiomics of the ablation zone (AZ) can predict local tumour progression (LTP) after thermal for colorectal liver metastases (CRLM). Materials and methods Eighty-two patients with 127 CRLM were included. Radiomics features (with different filters) extracted from AZ a 10 mm periablational rim (PAR)on portal-venous-phase CT up to 8 weeks ablation. Multivariable stepwise Cox regression analyses used LTP based on clinical features. Performance (concordance [c]-statistics) models was compared performance in an ‘independent’ dataset approximated bootstrapped leave-one-out-cross-validation (LOOCV). Results Thirty-three lesions (26 %) developed LTP. Median follow-up 21 months (range 6−115). The combined model, combination features, included chemotherapy (HR 0.50, p = 0.024), cT-stage 10.13, 0.016), lesion size 1.11, <0.001), AZ_Skewness 1.58, AZ_Uniformity 0.45, 0.002), PAR_Mean 0.52, 0.008), PAR_Skewness 1.67, 0.019) PAR_Uniformity 3.35, < 0.001) as relevant predictors predictive model (after LOOCV) yielded c-statistic 0.78 (95 %CI 0.65−0.87), or only (c-statistic 0.74 0.58−0.84) 0.65 0.52−0.83), respectively). Conclusion Combining better performing prediction than only. PAR may have potential aid during CRLM.
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ژورنال
عنوان ژورنال: European Journal of Radiology
سال: 2021
ISSN: ['0720-048X', '1872-7727']
DOI: https://doi.org/10.1016/j.ejrad.2021.109773